The focus of most emerging therapeutic strategies currently is on developing glycolysis and lactate inhibitors, with few interventions directly targeting Kla pathways, leaving significant room for exploration
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doi: 10.1158/0008-5472.Can-20-0600 90 AlessioMMariaFIolandaSMariaCVRosannaGAnnaDGet al
The gut microbiota shapes intestinal immune responses during health and disease
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Intriguingly, high intracellular cholesterol load in PAMP-activated microglia attenuated the expression of genes related to innate antiviral response ( Ifna2 , Ifnb1 , Ddx58 ), genes involved in chemotaxis ( Ccr6 , Cd14 , Cxcl10 ), and members of the pentraxin family, such as Crp (C-reactive protein) and Apcs (amyloid P component, serum)